How to Setup Out of Office Replies in Outlook 2010
In Outlook 2010 you can setup Out of Office replies just like in previous versions of Outlook. But this has now been renamed to “Automatic Replys”. You can now setup a diffrent message to people inside you company and external emails.
Out of Office (Auto Replies)
- Open Outlook and click on the File menu
- In the File Menu click on Info and then Automatic Replies
- You can now turn on automatic replies permanantely, during a certain time period and setup two seperate messages to people inside you company and external emails.


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this setting for if you are using Exchange server account. But if you are using normal account then you can create a rule for setting up Office of replies: read this
http://www.authorcode.com/how-to-set-up-out-of-office-reply-in-outlook-2010/